Antibiotics in acute bronchitis: a meta-analysis.

PurposeMost patients with acute bronchitis who seek medical care are treated with antibiotics, although the effectiveness of this intervention is uncertain. We performed a meta-analysis of randomized, controlled trials to estimate the effectiveness of antibiotics in the treatment of acute bronchitis.Subjects and methodsEnglish-language studies published January 1966 to April 1998 were retrieved using MEDLINE, bibliographies, and consultation with experts. Only randomized trials that enrolled otherwise healthy patients with a diagnosis of acute bronchitis, used an antibiotic in the treatment group and a placebo in the control group, and provided sufficient data to calculate an effect size were included.ResultsWe identified eight randomized controlled trials that satisfied all inclusion criteria. These studies used one of three antibiotics (erythromycin, doxycycline, trimethoprim/sulfamethoxazole). The use of antibiotics decreased the duration of cough and sputum production by approximately one-half day (summary effect size 0.21; 95% CI, 0.05 to 0.36). For specific symptoms, there were nonsignificant trends favoring the use of antibiotics: a decrease of 0.4 days of purulent sputum (95% CI, -0.1 to 0.8), a decrease of 0.5 days of cough (95% CI, -0.1 to 1.1), and a decrease of 0.3 days lost from work (95% CI, -0.6 to 1.1).ConclusionThis meta-analysis suggests a small benefit from the use of the antibiotics erythromycin, doxycycline, or trimethoprim/sulfamethoxazole in the treatment of acute bronchitis in otherwise healthy patients. As this small benefit must be weighed against the risk of side effects and the societal cost of increasing antibiotic resistance, we believe that the use of antibiotics is not justified in these patients

Single File Diffusion enhancement in a fluctuating modulated 1D channel

We show that the diffusion of a single file of particles moving in a fluctuating modulated 1D channel is enhanced with respect to the one in a bald pipe. This effect, induced by the fluctuations of the modulation, is favored by the incommensurability between the channel potential modulation and the moving file periodicity. This phenomenon could be of importance in order to optimize the critical current in superconductors, in particular in the case where mobile vortices move in 1D channels designed by adapted patterns of pinning sites.Comment: 4 pages, 4 figure

Initiating University Reform: Experience from Sub-Saharan Africa.

A journal article.The rapid numerical growth of African universities has prompted little evolution in institutional forms. Some universities may embrace a specialized disciplinary focus such as agriculture, education or science and technology, but in structure and process they remain remarkably similar. Little institutional differentiation has occurred within higher education systems, and legacies from the pre-independence era still shape the form and substance of African universities in important ways. These include the high cost model of publicly funded residential instruction, strong curricular emphasis on the humanities and social sciences, and an elitist orientation. As a result, these systems have been hard pressed to meet the rapidly rising social demand for access to university education in a context of significant economic, political and technological change. The challenge is daunting, but African governments and their universities have begun to respond. What lessons can be learned from this emerging experience? The following discussion draws upon current examples of promising practice to suggest options for African governments, universities and donors to consider in their efforts to foster higher education reform

The evolution of sperm morphometry in pheasants

Postcopulatory sexual selection is thought to be a potent evolutionary force driving the diversification of sperm shape and function across species. In birds, insemination and fertilisation are separated in time and sperm storage increases the duration of sperm female interaction and hence the opportunity for sperm competition and cryptic female choice. We performed a comparative study of 24 pheasant species (Phasianidae, Galliformes) to establish the relative importance of sperm competition and the duration of sperm storage for the evolution of sperm morphometry (i.e. size of different sperm traits). We found that sperm size traits were negatively associated with the duration of sperm storage but were independent of the risk of sperm competition estimated from relative testis mass. Our study emphasises the importance of female reproductive biology for the evolution of sperm morphometry particularly in sperm storing taxa

Spectral Features of the Proximity Effect

We calculate the local density of states (LDOS) of a superconductor-normal metal sandwich at arbitrary impurity concentration. The presence of the superconductor induces a gap in the normal metal spectrum that is proportional to the inverse of the elastic mean free path $l$ for rather clean systems. For a mean free path much shorter than the thickness of the normal metal, we find a gap size proportional to $l$ that approaches the behavior predicted by the Usadel equation (diffusive limit).Comment: LT22 proceeding

Kinetic modelling of runaway electron avalanches in tokamak plasmas

Runaway electrons (REs) can be generated in tokamak plasmas if the accelerating force from the toroidal electric field exceeds the collisional drag force due to Coulomb collisions with the background plasma. In ITER, disruptions are expected to generate REs mainly through knock-on collisions, where enough momentum can be transferred from existing runaways to slow electrons to transport the latter beyond a critical momentum, setting off an avalanche of REs. Since knock-on runaways are usually scattered off with a significant perpendicular component of the momentum with respect to the local magnetic field direction, these particles are highly magnetized. Consequently, the momentum dynamics require a full 3-D kinetic description, since these electrons are highly sensitive to the magnetic non-uniformity of a toroidal configuration. A bounce-averaged knock-on source term is derived. The generation of REs from the combined effect of Dreicer mechanism and knock-on collision process is studied with the code LUKE, a solver of the 3-D linearized bounce-averaged relativistic electron Fokker-Planck equation, through the calculation of the response of the electron distribution function to a constant parallel electric field. This work shows that the avalanche effect can be important even in non-disruptive scenarios. RE formation through knock-on collisions is found to be strongly reduced when taking place off the magnetic axis, since trapped electrons cannot contribute to the RE population. The relative importance of the avalanche mechanism is investigated as a function of the key parameters for RE formation; the plasma temperature and the electric field strength. In agreement with theoretical predictions, the simulations show that in low temperature and E-field knock-on collisions are the dominant source of REs and can play a significant role for RE generation, including in non-disruptive scenarios.Comment: 23 pages, 12 figure

Anisotropy and effective dimensionality crossover of the fluctuation conductivity of hybrid superconductor/ferromagnet structures

We study the fluctuation conductivity of a superconducting film, which is placed to perpendicular non-uniform magnetic field with the amplitude $H_0$ induced by the ferromagnet with domain structure. The conductivity tensor is shown to be essentially anisotropic. The magnitude of this anisotropy is governed by the temperature and the typical width of magnetic domains $d$. For $d\ll L_{H_0}=\sqrt{\Phi_0/H_0}$ the difference between diagonal fluctuation conductivity components $\Delta\sigma_\parallel$ along the domain walls and $\Delta\sigma_\perp$ across them has the order of $(d/L_{H_0})^4$. In the opposite case for $d\gg L_{H_0}$ the fluctuation conductivity tensor reveals effective dimensionality crossover from standard two-dimensional $(T-T_c)^{-1}$ behavior well above the critical temperature $T_c$ to the one-dimensional $(T-T_c)^{-3/2}$ one close to $T_c$ for $\Delta\sigma_\parallel$ or to the $(T-T_c)^{-1/2}$ dependence for $\Delta\sigma_\perp$. In the intermediate case $d\approx L_{H_0}$ for a fixed temperature shift from $T_c$ the dependence $\Delta\sigma_\parallel(H_0)$ is shown to have a minimum at $H_0\sim\Phi_0/d^2$ while $\Delta\sigma_\perp(H_0)$ is a monotonically increasing function.Comment: 11 pages, 8 figure